Calcineurin inhibitors have markedly reduced acute rejection rates in renal transplantation, thus significantly improved Bodysuits short-term outcome.The beneficial effects are, however, tampered by acute and chronic nephrotoxicity leading to interstitial fibrosis and tubular atrophy, which impairs long-term allograft survival.The mineralocorticoid hormone aldosterone induces fibrosis in numerous Style organs, including the kidney.
Evidence from animal models suggests a beneficial effect of aldosterone antagonism in reducing calcineurin inhibitor-induced nephrotoxicity.This review summarizes current evidence of mineralocorticoid receptor antagonism in animal models of calcineurin inhibitor-induced nephrotoxicity and the results from studies of mineralocorticoid antagonism in renal transplant patients.